Structurally constrained protein evolution: results from a lattice simulation
نویسندگان
چکیده
منابع مشابه
Structurally constrained protein evolution: results from a lattice simulation
We simulate the evolution of a protein-like sequence subject to point mutations, imposing conservation of the ground state, thermodynamic stability and fast folding. Our model is aimed at describing neutral evolution of natural proteins. We use a cubic lattice model of the protein structure and test the neutrality conditions by extensive Monte Carlo simulations. We observe that sequence space i...
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Evolutionary amino acid replacement rates depend on local structural environment (Overington et al. 1992; Koshi and Goldstein 1995). Recent models of protein evolution aim to take such site heterogeneity into account by using site-specific amino acid replacement matrices (Lio and Goldman 1998; Thorne 2000). This is a difficult task, mainly because of a lack-of-data problem: too many sequences w...
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ژورنال
عنوان ژورنال: The European Physical Journal B
سال: 2000
ISSN: 1434-6028
DOI: 10.1007/s100510051140